Substrate-mediated Stabilization of a Tetrameric Drug Target Reveals Achilles Heel in Anthrax

Bacillus anthracis is a Gram-positive spore-forming bacterium that causes anthrax. With the increased threat of anthrax in biowarfare, there is an urgent need to characterize new antimicrobial targets from B. anthracis. One such target is dihydrodipicolinate synthase (DHDPS), which catalyzes the com...

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Bibliografiske detaljer
Main Authors: Voss, Jarrod E., Scally, Stephen W., Taylor, Nicole L., Atkinson, Sarah C., Griffin, Michael D. W., Hutton, Craig A., Parker, Michael W., Alderton, Malcolm R., Gerrard, Juliet A., Dobson, Renwick C. J., Dogovski, Con, Perugini, Matthew A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2010
Fag:
Enzymology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2820746/
https://ncbi.nlm.nih.gov/pubmed/19948665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.038166
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