Substrate-mediated Stabilization of a Tetrameric Drug Target Reveals Achilles Heel in Anthrax

Bacillus anthracis is a Gram-positive spore-forming bacterium that causes anthrax. With the increased threat of anthrax in biowarfare, there is an urgent need to characterize new antimicrobial targets from B. anthracis. One such target is dihydrodipicolinate synthase (DHDPS), which catalyzes the com...

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Détails bibliographiques
Auteurs principaux: Voss, Jarrod E., Scally, Stephen W., Taylor, Nicole L., Atkinson, Sarah C., Griffin, Michael D. W., Hutton, Craig A., Parker, Michael W., Alderton, Malcolm R., Gerrard, Juliet A., Dobson, Renwick C. J., Dogovski, Con, Perugini, Matthew A.
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2010
Sujets:
Enzymology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2820746/
https://ncbi.nlm.nih.gov/pubmed/19948665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.038166
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