Lethal Antibody Enhancement of Dengue Disease in Mice Is Prevented by Fc Modification

Immunity to one of the four dengue virus (DV) serotypes can increase disease severity in humans upon subsequent infection with another DV serotype. Serotype cross-reactive antibodies facilitate DV infection of myeloid cells in vitro by promoting virus entry via Fcγ receptors (FcγR), a process known...

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Detalhes bibliográficos
Main Authors: Balsitis, Scott J., Williams, Katherine L., Lachica, Ruben, Flores, Diana, Kyle, Jennifer L., Mehlhop, Erin, Johnson, Syd, Diamond, Michael S., Beatty, P. Robert, Harris, Eva
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2820409/
https://ncbi.nlm.nih.gov/pubmed/20168989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1000790
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