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Defining the Structural Consequences of Mechanism-Based Inactivation of Mammalian Cytochrome P450 2B4 Using Resonance Raman Spectroscopy
Given the potent oxidizing strength of cytochrome P450 intermediates it is not surprising that certain substrates can give rise to reactive species capable of attacking the heme or critical distal pocket protein residues to irreversibly modify the enzyme in a process known as mechanism-based (MB) in...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2820406/ https://ncbi.nlm.nih.gov/pubmed/20078059 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja910276s |
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