Monitoring Genomic Sequences during SELEX Using High-Throughput Sequencing: Neutral SELEX

BACKGROUND: SELEX is a well established in vitro selection tool to analyze the structure of ligand-binding nucleic acid sequences called aptamers. Genomic SELEX transforms SELEX into a tool to discover novel, genomically encoded RNA or DNA sequences binding a ligand of interest, called genomic aptam...

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Bibliographic Details
Main Authors: Zimmermann, Bob, Gesell, Tanja, Chen, Doris, Lorenz, Christina, Schroeder, Renée
Format: Artigo
Language:Inglês
Published: Public Library of Science 2010
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2820082/
https://ncbi.nlm.nih.gov/pubmed/20161784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0009169
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