Suppression of Wnt signaling by Dkk1 attenuates PTH-mediated stromal cell response and new bone formation

Parathyroid hormone (PTH) suppresses Dickkopf 1 (Dkk1) expression in osteoblasts. To determine whether this suppression is essential for PTH-mediated Wnt signaling and bone formation, we examined mice that overexpress Dkk1 in osteoblasts (Dkk1 mice). Dkk1 mice were osteopenic due to abnormal osteobl...

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Hoofdauteurs: Guo, Jun, Liu, Minlin, Yang, Dehong, Bouxsein, Mary L, Saito, Hiroaki, Galvin, R J Sells, Kuhstoss, Stuart A., Thomas, Clare C, Schipani, Ernestina, Baron, Roland, Bringhurst, F Richard, Kronenberg, Henry M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2010
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2819982/
https://ncbi.nlm.nih.gov/pubmed/20142103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2009.12.007
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