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Deciphering the Late Biosynthetic Steps of Antimalarial Compound FR-900098
FR-900098 is a potent chemotherapeutic agent for the treatment of malaria. Here we report the heterologous production of this compound in E. coli by re-constructing the entire biosynthetic pathway using a three plasmid system. Based on this system, whole cell feeding assays in combination with in vi...
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| 主要な著者: | , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2010
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2819980/ https://ncbi.nlm.nih.gov/pubmed/20142041 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2009.12.009 |
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