RESTORATION OF ENDOGENOUS WILD-TYPE p53 ACTIVITY IN A GLIOBLASTOMA CELL LINE WITH INTRINSIC TEMPERATURE-SENSITIVE p53 INDUCES GROWTH ARREST BUT NOT APOPTOSIS

p53 protein is a transcription factor involved in multiple tumor-suppressor activities including cell cycle control and apoptosis. TP53 gene is frequently mutated in glioblastoma, suggesting the importance of inactivation of this gene product in gliomagenesis. Restoration of p53 function in glioblas...

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Detalhes bibliográficos
Main Authors: Ikeda, Jun, Tada, Mitsuhiro, Ishii, Nobuaki, Saya, Hideyuki, Tsuchiya, Kazuhiko, Okaichi, Kumio, Mishima, Kazuhiko, Sawamura, Yutaka, Fulci, Giulia, Liu, Ta-Jen, Van Meir, Erwin G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2001
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2819747/
https://ncbi.nlm.nih.gov/pubmed/11668476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.1431
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