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Proliferation of aneuploid human cells is limited by a p53-dependent mechanism

Most solid tumors are aneuploid, and it has been proposed that aneuploidy is the consequence of an elevated rate of chromosome missegregation in a process called chromosomal instability (CIN). However, the relationship of aneuploidy and CIN is unclear because the proliferation of cultured diploid ce...

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Autori principali: Thompson, Sarah L., Compton, Duane A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Rockefeller University Press 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2819684/
https://ncbi.nlm.nih.gov/pubmed/20123995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200905057
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