BMS-536924 Reverses IGF-IR-induced Transformation of Mammary Epithelial Cells and Causes Growth Inhibition and Polarization of MCF7 Cells

PURPOSE: To test the ability of a new IGF-IR tyrosine kinase inhibitor BMS-536924 to reverse the ability of constitutively active IGF-IR (CD8-IGF-IR) to transform MCF10A cells, and to examine the effect of the inhibitor on a range of human breast cancer cell lines. EXPERIMENTAL DESIGN: CD8-IGF-IR-MC...

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Main Authors: Litzenburger, Beate C., Kim, Hyun-Jung, Kuiatse, Isere, Carboni, Joan M., Attar, Ricardo M., Gottardis, Marco M., Fairchild, Craig R., Lee, Adrian V.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2819349/
https://ncbi.nlm.nih.gov/pubmed/19118050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-08-0801
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