Uncoupled Cardiac Nitric Oxide Synthase Mediates Diastolic Dysfunction

BACKGROUND: Heart failure with preserved ejection fraction is one consequence of hypertension and caused by impaired cardiac diastolic relaxation. Nitric oxide (NO) is a known modulator of cardiac relaxation. Hypertension can lead to a reduction in vascular NO, in part because nitric oxide synthase...

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Auteurs principaux: Silberman, Gad A., Fan, Tai-Hwang M., Liu, Hong, Jiao, Zhe, Xiao, Hong D., Lovelock, Joshua D., Boulden, Beth M., Widder, Julian, Fredd, Scott, Bernstein, Kenneth E., Wolska, Beata M., Dikalov, Sergey, Harrison, David G., Dudley, Samuel C.
Format: Artigo
Langue:Inglês
Publié: 2010
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2819317/
https://ncbi.nlm.nih.gov/pubmed/20083682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.109.883777
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