Sequence Verification of Oligonucleotides Containing Multiple Arylamine Modifications by Enzymatic Digestion and Liquid Chromatography Mass Spectrometry (LC/MS)

An analytical method for the structure differentiation of arylamine modified oligonucleotides (ODNs) using on-line LC/MS analysis of raw exonuclease digests is described. Six different dodeca ODNs derived from the reaction of N-acetoxy-N-(trifluoroacetyl)-2-aminofluorene with the dodeca oligonucleot...

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Bibliografische gegevens
Hoofdauteurs: Gao, Lan, Zhang, Li, Cho, Bongsup P., Chiarelli, M. Paul
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2008
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2819294/
https://ncbi.nlm.nih.gov/pubmed/18524623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jasms.2008.04.034
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