Adipocyte-Specific Glucocorticoid Inactivation Protects Against Diet-Induced Obesity

Local glucocorticoid (GC) action depends on intracellular GC metabolism by 11β-hydroxysteroid dehydrogenases (11βHSDs). 11βHSD1 activates GCs, while 11βHSD2 inactivates GCs. Adipocyte-specific amplification of GCs through transgenic overexpression of 11βHSD1 produces visceral obesity and the metabol...

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Bibliografski detalji
Glavni autori: Kershaw, Erin E., Morton, Nicholas M., Dhillon, Harveen, Ramage, Lynne, Seckl, Jonathan R., Flier, Jeffrey S.
Format: Artigo
Jezik:Inglês
Izdano: 2005
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2819172/
https://ncbi.nlm.nih.gov/pubmed/15793240
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