Molecular mechanism of retinoblastoma gene inactivation in retinoblastoma cell line Y79.

Formation of retinoblastoma, a cancer arising in the retinas of young children, is determined by mutational inactivation of an autosomal gene (RB), which has been molecularly cloned. Whereas all normal tissues and many tumor cells express an RB mRNA of 4.7 kilobases, six of six retinoblastomas were...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Lee, E Y, Bookstein, R, Young, L J, Lin, C J, Rosenfeld, M G, Lee, W H
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1988
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC281896/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3413073/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.85.16.6017
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