The RNF8/RNF168 ubiquitin ligase cascade facilitates class switch recombination

An effective immune response requires B cells to produce several classes of antibodies through the process of class switch recombination (CSR). Activation-induced cytidine deaminase initiates CSR by deaminating deoxycytidines at switch regions within the Ig locus. This activity leads to double-stran...

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Main Authors: Ramachandran, Shaliny, Chahwan, Richard, Nepal, Rajeev M., Frieder, Darina, Panier, Stephanie, Roa, Sergio, Zaheen, Ahmad, Durocher, Daniel, Scharff, Matthew D., Martin, Alberto
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2009
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2818930/
https://ncbi.nlm.nih.gov/pubmed/20080757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0913790107
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