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The RNF8/RNF168 ubiquitin ligase cascade facilitates class switch recombination
An effective immune response requires B cells to produce several classes of antibodies through the process of class switch recombination (CSR). Activation-induced cytidine deaminase initiates CSR by deaminating deoxycytidines at switch regions within the Ig locus. This activity leads to double-stran...
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| 主要な著者: | , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2009
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2818930/ https://ncbi.nlm.nih.gov/pubmed/20080757 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0913790107 |
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