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Three conformational snapshots of the hepatitis C virus NS3 helicase reveal a ratchet translocation mechanism
A virally encoded superfamily-2 (SF2) helicase (NS3h) is essential for the replication of hepatitis C virus, a leading cause of liver disease worldwide. Efforts to elucidate the function of NS3h and to develop inhibitors against it, however, have been hampered by limited understanding of its molecul...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2010
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2818896/ https://ncbi.nlm.nih.gov/pubmed/20080715 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0913380107 |
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