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A repressor heterodimer binds to a chimeric operator.

Replacement of the solvent-exposed residues of the DNA recognition helix of the 434 repressor with the corresponding residues of the P22 repressor generates a hybrid protein, 434R[alpha 3(P22R)], which binds specifically to P22 operators. We show here that a new DNA-binding specificity is generated...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Hollis, M, Valenzuela, D, Pioli, D, Wharton, R, Ptashne, M
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1988
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC281859/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3413061/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.85.16.5834
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