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EWS/FLI1 Oncogene Activates Caspase 3 Transcription and Triggers Apoptosis In Vivo
EWS/FLI1 is a fusion gene product generated by a chromosomal translocation t(11; 22)(q24; q12) found in Ewing sarcoma. EWS/FLI1 encodes an aberrant transcription factor with oncogenic properties in vitro. Paradoxically, expression of EWS/FLI1 in non-transformed primary cells results in apoptosis, bu...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2818579/ https://ncbi.nlm.nih.gov/pubmed/20103643 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-1993 |
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