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Enzastaurin induces H2AX phosphorylation to regulate apoptosis via MAPK signalling in Malignant Glioma Cells
Enzastaurin is an acyclic bisindolylmaleimide derived from staurosporine that acts as an ATP competitor, and interferes with the activity of protein kinase C isoforms. Our previous studies have shown that clinically achievable concentrations of this agent induce apoptosis in many glioma cell lines....
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| Main Authors: | , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2009
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2818487/ https://ncbi.nlm.nih.gov/pubmed/19913408 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejca.2009.10.014 |
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