IL-1RA blocks E. coli-induced suppression of Arc and long-term memory in aged F344 × BN F1 rats

In normal aging, a peripheral immune challenge induces a sensitized and protracted neuroinflammatory response in parallel with long-term memory (LTM) impairments. Proinflammatory mediators of neuroinflammation impair LTM, synaptic plasticity and LTP. The immediate early gene Arc is considered a crit...

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Detalhes bibliográficos
Main Authors: Frank, Matthew G., Barrientos, Ruth M., Hein, Amy M., Biedenkapp, Joseph C., Watkins, Linda R., Maier, Steven F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2818379/
https://ncbi.nlm.nih.gov/pubmed/19822205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbi.2009.10.005
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