Loss of MARCH5 mitochondrial E3 ubiquitin ligase induces cellular senescence through dynamin-related protein 1 and mitofusin 1

Mitochondria constantly divide and combine through fission and fusion activities. MARCH5, a mitochondrial E3 ubiquitin ligase, has been identified as a molecule that binds mitochondrial fission 1 protein (hFis1), dynamin-related protein 1 (Drp1) and mitofusin 2 (Mfn2), key proteins in the control of...

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Main Authors: Park, Yong-Yea, Lee, Seungmin, Karbowski, Mariusz, Neutzner, Albert, Youle, Richard J., Cho, Hyeseong
Formato: Artigo
Idioma:Inglês
Publicado em: Company of Biologists 2010
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Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2818198/
https://ncbi.nlm.nih.gov/pubmed/20103533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.061481
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