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β-strand interactions at the domain interface critical for the stability of human lens γD-crystallin
Human age-onset cataracts are believed to be caused by the aggregation of partially unfolded or covalently damaged lens crystallin proteins; however, the exact molecular mechanism remains largely unknown. We have used microseconds of molecular dynamics simulations with explicit solvent to investigat...
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| Huvudupphovsmän: | , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
Wiley Subscription Services, Inc., A Wiley Company
2010
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2817848/ https://ncbi.nlm.nih.gov/pubmed/19937657 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.296 |
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