Short-term inhibition of p53 combined with keratinocyte growth factor improves thymic epithelial cell recovery and enhances T-cell reconstitution after murine bone marrow transplantation

Myeloablative conditioning before bone marrow transplantation (BMT) results in thymic epithelial cell (TEC) injury, T-cell immune deficiency, and susceptibility to opportunistic infections. Conditioning regimen–induced TEC damage directly contributes to slow thymopoietic recovery after BMT. Keratino...

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Detalhes bibliográficos
Main Authors: Kelly, Ryan M., Goren, Emily M., Taylor, Patricia A., Mueller, Scott N., Stefanski, Heather E., Osborn, Mark J., Scott, Hamish S., Komarova, Elena A., Gudkov, Andrei V., Holländer, Georg A., Blazar, Bruce R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2010
Assuntos:
Transplantation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2817635/
https://ncbi.nlm.nih.gov/pubmed/19965631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-05-223198
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