Donor T-cell alloreactivity against host thymic epithelium limits T-cell development after bone marrow transplantation

Acute graft-versus-host disease (aGVHD) impairs thymus-dependent T-cell regeneration in recipients of allogeneic bone marrow transplants through yet to be defined mechanisms. Here, we demonstrate in mice that MHC-mismatched donor T cells home into the thymus of unconditioned recipients. There, activ...

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Autori principali: Hauri-Hohl, Mathias M., Keller, Marcel P., Gill, Jason, Hafen, Katrin, Pachlatko, Esther, Boulay, Thomas, Peter, Annick, Holländer, Georg A., Krenger, Werner
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2007
Soggetti:
Transplantation
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1874583/
https://ncbi.nlm.nih.gov/pubmed/17213290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-07-034157
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