Genetic and Functional Dissection of HTRA1 and LOC387715 in Age-Related Macular Degeneration

A common haplotype on 10q26 influences the risk of age-related macular degeneration (AMD) and encompasses two genes, LOC387715 and HTRA1. Recent data have suggested that loss of LOC387715, mediated by an insertion/deletion (in/del) that destabilizes its message, is causally related with the disorder...

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主要な著者: Yang, Zhenglin, Tong, Zongzhong, Chen, Yuhong, Zeng, Jiexi, Lu, Fang, Sun, Xufang, Zhao, Chao, Wang, Kevin, Davey, Lisa, Chen, Haoyu, London, Nyall, Muramatsu, Daisuke, Salasar, Francesca, Carmona, Ruben, Kasuga, Daniel, Wang, Xiaolei, Bedell, Matthew, Dixie, Manjuxia, Zhao, Peiquan, Yang, Ruifu, Gibbs, Daniel, Liu, Xiaoqi, Li, Yan, Li, Cai, Li, Yuanfeng, Campochiaro, Betsy, Constantine, Ryan, Zack, Donald J., Campochiaro, Peter, Fu, Yinbin, Li, Dean Y., Katsanis, Nicholas, Zhang, Kang
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2010
主題:
Research Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2816682/
https://ncbi.nlm.nih.gov/pubmed/20140183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1000836
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