Lack of association between oestrogen receptor polymorphisms and change in bone mineral density with tamoxifen therapy

BACKGROUND: Tamoxifen, a selective oestrogen receptor (ER) modulator, increases bone mineral density (BMD) in postmenopausal women and decreases BMD in premenopausal women. We hypothesised that inherited variants in candidate genes involved in oestrogen signalling and tamoxifen metabolism might be a...

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Dettagli Bibliografici
Autori principali: Henry, N L, Nguyen, A, Azzouz, F, Li, L, Robarge, J, Philips, S, Cao, D, Skaar, T C, Rae, J M, Storniolo, A M, Flockhart, D A, Hayes, D F, Stearns, V
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2010
Soggetti:
Clinical Study
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2816645/
https://ncbi.nlm.nih.gov/pubmed/19953095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6605460
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