Association between CYP2D6 genotype and tamoxifen-induced hot flashes in a prospective cohort

PURPOSE: Women with reduced CYP2D6 activity have low endoxifen concentrations and likely worse long term benefits from tamoxifen. We investigated the association between CYP2D6 genotype and tamoxifen-induced hot flashes, in a prospective cohort. METHODS: We collected hot flash frequency and severity...

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Detalhes bibliográficos
Principais autores: Henry, N. Lynn, Rae, James M., Li, Lang, Azzouz, Faouzi, Skaar, Todd C., Desta, Zereunesay, Sikora, Matthew J., Philips, Santosh, Nguyen, Anne, Storniolo, Anna Maria, Hayes, Daniel F., Flockhart, David A., Stearns, Vered
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2746261/
https://ncbi.nlm.nih.gov/pubmed/19153830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10549-009-0309-1
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