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Evolution at a High Imposed Mutation Rate: Adaptation Obscures the Load in Phage T7
Evolution at high mutation rates is expected to reduce population fitness deterministically by the accumulation of deleterious mutations. A high enough rate should even cause extinction (lethal mutagenesis), a principle motivating the clinical use of mutagenic drugs to treat viral infections. The im...
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| Main Authors: | , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Genetics Society of America
2010
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2815918/ https://ncbi.nlm.nih.gov/pubmed/19858285 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.109.108803 |
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