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Evolution at a High Imposed Mutation Rate: Adaptation Obscures the Load in Phage T7

Evolution at high mutation rates is expected to reduce population fitness deterministically by the accumulation of deleterious mutations. A high enough rate should even cause extinction (lethal mutagenesis), a principle motivating the clinical use of mutagenic drugs to treat viral infections. The im...

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Detalhes bibliográficos
Main Authors: Springman, R., Keller, T., Molineux, I. J., Bull, J. J.
Formato: Artigo
Idioma:Inglês
Publicado em: Genetics Society of America 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2815918/
https://ncbi.nlm.nih.gov/pubmed/19858285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.109.108803
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