Investigating AP-2 and YY1 protein expression as a cause of high HER2 gene transcription in breast cancers with discordant HER2 gene amplification

INTRODUCTION: Candidacy for anti-HER2 adjuvant therapy in breast cancer is assessed using tumour HER2 status but recently it has been proposed that the transcription factors AP-2α and YY1 may cause Her2 protein overexpression independently of gene amplification. METHODS: We characterised AP-2α/β, AP...

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Main Authors: Powe, Desmond G, Akhtar, Gulfareen, Habashy, Hany Onsy, Abdel-Fatah, Tarek, Rakha, Emad A, Green, Andrew R, Ellis, Ian O
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2009
Fag:
Research article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2815554/
https://ncbi.nlm.nih.gov/pubmed/20025767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr2461
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