A selective eradication of human nonhereditary breast cancer cells by phenanthridine-derived polyADP-ribose polymerase inhibitors

INTRODUCTION: PARP-1 (polyADP-ribose polymerase-1) is known to be activated in response to DNA damage, and activated PARP-1 promotes DNA repair. However, a recently disclosed alternative mechanism of PARP-1 activation by phosphorylated externally regulated kinase (ERK) implicates PARP-1 in a vast nu...

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Main Authors: Inbar-Rozensal, Dana, Castiel, Asher, Visochek, Leonid, Castel, David, Dantzer, Françoise, Izraeli, Shai, Cohen-Armon, Malka
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2009
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Research article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2815540/
https://ncbi.nlm.nih.gov/pubmed/19891779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr2445
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