Francisella tularensis T-Cell Antigen Identification Using Humanized HLA-DR4 Transgenic Mice

There is no licensed vaccine against the intracellular pathogen Francisella tularensis. The use of conventional mouse strains to screen protective vaccine antigens may be problematic, given the differences in the major histocompatibility complex (MHC) binding properties between murine and human anti...

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Main Authors: Yu, Jieh-Juen, Goluguri, TataReddy, Guentzel, M. Neal, Chambers, James P., Murthy, Ashlesh K., Klose, Karl E., Forsthuber, Thomas G., Arulanandam, Bernard P.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2010
Fag:
Microbial Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2815527/
https://ncbi.nlm.nih.gov/pubmed/20016043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CVI.00361-09
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