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Herpes simplex virus (HSV)-specific T cells activated in the absence of IFN-gamma express alternative effector functions but are not protective against genital HSV-2 infection

Interferon gamma (IFNγ) is important for immune resistance to herpes simplex virus (HSV) infection. To examine the influence of IFNγ on the development of HSV-specific immune responses and test for IFNγ-independent adaptive immune mechanisms of protection, IFNγ-deficient mice (IFNγ(−/−)) were immuni...

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Detalhes bibliográficos
Main Authors: Johnson, Alison J., Nelson, Michelle H., Bird, Melanie D., Chu, Chin-Fun, Milligan, Gregg N.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2815080/
https://ncbi.nlm.nih.gov/pubmed/19942296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jri.2009.09.007
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