Clearance of Herpes Simplex Virus Type 2 by CD8(+) T Cells Requires Gamma Interferon and either Perforin- or Fas-Mediated Cytolytic Mechanisms

The T-cell-mediated resolution of herpes simplex virus type 2 (HSV-2) genital infections is not fully understood. In these studies, the mechanisms by which CD8(+) T cells clear virus from the genital epithelium were examined. Ovalbumin (OVA)-specific CD8(+) T cells from OT-I transgenic mice cleared...

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Detalhes bibliográficos
Main Authors: Dobbs, Melanie E., Strasser, Jane E., Chu, Chin-Fun, Chalk, Claudia, Milligan, Gregg N.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1287581/
https://ncbi.nlm.nih.gov/pubmed/16282454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.23.14546-14554.2005
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