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Enhancement of arsenic trioxide cytotoxicity by dietary isothiocyanates in human leukemic cells via a reactive oxygen species dependent mechanism

Although clearly effective in acute promyelocytic leukemia (APL), arsenic trioxide (ATO) demonstrates little clinical benefit as a single agent in the treatment of non-APL hematological malignancies. We screened a library of 2000 marketed drugs and naturally occurring compounds to identify agents th...

詳細記述

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書誌詳細
主要な著者: Doudican, Nicole A., Bowling, Benjamin, Orlow, Seth J.
フォーマット: Artigo
言語:Inglês
出版事項: 2009
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2815001/
https://ncbi.nlm.nih.gov/pubmed/19540589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.leukres.2009.05.017
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