Decrease of Foxp3+ Treg cell number and acquisition of effector cell phenotype during lethal infection

Using a model of lethal oral infection with Toxoplasma gondii, we examined the fate of both induced and natural regulatory T (Treg) cells in the face of strong inflammatory responses occurring in a tolerogenic-prone environment. We found that during highly T helper 1 (Th1) cell-polarized mucosal imm...

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Main Authors: Oldenhove, Guillaume, Bouladoux, Nicolas, Wohlfert, Elizabeth A., Hall, Jason, Chou, David, Dos santos, Liliane, O’Brien, Shaun, Blank, Rebecca, Lamb, Erika, Natarajan, Sundar, Kastenmayer, Robin, Hunter, Christopher, Grigg, Michael E., Belkaid, Yasmine
Format: Artigo
Sprog:Inglês
Udgivet: 2009
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2814877/
https://ncbi.nlm.nih.gov/pubmed/19896394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2009.10.001
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