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Mechanism of metabolic activation and DNA adduct formation by the human carcinogen diethylstilbestrol: The defining link to natural estrogens
Diethylstilbestrol (DES) is a human carcinogen, based on sufficient epidemiological evidence. DES is mainly metabolized to its catechol, 3′-hydroxyDES (3′-OH-DES), which can further oxidize to DES-3′,4′-quinone (DES-3′,4′-Q). Similarly to estradiol-3,4-quinone, the reaction of DES-3′,4′-Q with DNA w...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2814601/ https://ncbi.nlm.nih.gov/pubmed/19089919 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.24113 |
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