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p53-mediated Down-regulation of the Human DNA Repair Gene O(6)- Methylguanine-DNA Methyltransferase (MGMT) via Interaction with Sp1 Transcription Factor
O(6)-Methylguanine-DNA methyltransferase (MGMT), a ubiquitous DNA repair protein, reverses mutagenic and cytotoxic effects of O(6)-alkylguanine in DNA induced by chemotherapeutic N-alkyl N-nitrosourea and procarbazine type drugs by dealkylating the adduct. MGMT expression is down-regulated by wild-t...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2814523/ https://ncbi.nlm.nih.gov/pubmed/19846904 |
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