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Heat Shock Protein 96 is Elevated in Rheumatoid Arthritis and Activates Macrophages primarily via TLR2 Signaling

Macrophages are important mediators of chronic inflammation and are prominent in the synovial lining and sublining of patients with rheumatoid arthritis (RA). Recently, we demonstrated increased toll like receptor (TLR) 2 and 4 expression and increased response to microbial TLR2 and TLR4 ligands in...

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Autori principali: Huang, Qi-Quan, Sobkoviak, Rudina, Jockheck-Clark, Angela, Shi, Bo, Mandelin, Arthur M., Tak, Paul Peter, Haines, G Kennith, Nicchitta, Christopher V., Pope, Richard M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2814438/
https://ncbi.nlm.nih.gov/pubmed/19342676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0801563
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