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Molecular and phenotypic reassessment of an infrequently used mouse model for spinal muscular atrophy
Proximal spinal muscular atrophy (SMA) results from loss of the survival motor neuron 1 (SMN1) gene, with retention of its nearly identical homolog, SMN2. There is a direct correlation between disease severity and SMN2 copy number. Mice do not have a Smn2 gene, and thus cannot naturally replicate th...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2814331/ https://ncbi.nlm.nih.gov/pubmed/19961830 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2009.11.090 |
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