Tumor Cellular Proteasome Inhibition and Growth Suppression by 8-Hydroxyquinoline and Clioquinol Requires Their Capabilities to Bind Copper and Transport Copper into Cells

We have previously reported that when mixed with copper, 8-hydroxyquinoline (8-OHQ) and its analog clioquinol (CQ) inhibited the proteasomal activity and proliferation in cultured human cancer cells. CQ treatment of high copper-containing human tumor xenografts also caused cancer suppression, associ...

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Bibliographic Details
Main Authors: Zhai, Shumei, Yang, Lei, Cui, Qiuzhi Cindy, Sun, Ying, Dou, Q. Ping, Yan, Bing
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2814311/
https://ncbi.nlm.nih.gov/pubmed/19809836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00775-009-0594-5
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