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Novel CD8(+) Treg suppress EAE by TGF-β- and IFN-γ-dependent mechanisms

Although CD8(+) Treg-mediated suppression has been described, CD8(+) Treg remain poorly characterized. Here we identify a novel subset of CD8(+) Treg that express latency-associated peptide (LAP) on their cell surface (CD8(+)LAP(+) cells) and exhibit regulatory activity in vitro and in vivo. Only a...

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Detalhes bibliográficos
Main Authors: Chen, Mei-Ling, Yan, Bo-Shiun, Kozoriz, Deneen, Weiner, Howard L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2814307/
https://ncbi.nlm.nih.gov/pubmed/19768696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.200939441
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