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Improving Enrichment of Circulating Fetal DNA for Genetic Testing: Size Fractionation Followed by Whole Gene Amplification

OBJECTIVE: Among the pitfalls of using cell-free fetal DNA in plasma for prenatal diagnosis is quality of the recovered DNA fragments and concomitant presence of maternal DNA (>95%). Our objective is to provide alternative methods for achieving enrichment and high-quality fetal DNA from plasma. M...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Jorgez, Carolina J., Bischoff, Farideh Z.
Format: Artigo
Sprache:Inglês
Veröffentlicht: S. Karger AG 2009
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2814146/
https://ncbi.nlm.nih.gov/pubmed/19776594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000235877
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