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Efficiency of whole genome amplification of single circulating tumor cells enriched by CellSearch and sorted by FACS

BACKGROUND: Tumor cells in the blood of patients with metastatic carcinomas are associated with poor survival. Knowledge of the cells’ genetic make-up can help to guide targeted therapy. We evaluated the efficiency and quality of isolation and amplification of DNA from single circulating tumor cells...

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Detalhes bibliográficos
Main Authors: Swennenhuis, Joost F, Reumers, Joke, Thys, Kim, Aerssens, Jeroen, Terstappen, Leon WMM
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3978840/
https://ncbi.nlm.nih.gov/pubmed/24286536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/gm510
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