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DNA Damage and Interstrand Cross-link Formation Upon Irradiation of Aryl Iodide C-Nucleotide Analogues
The 5-halopyrimidine nucleotides damage DNA upon UV-irradiation or exposure to γ-radiolysis via the formation of the 2'-deoxyuridin-5-yl σ-radical. The bromo and iodo derivatives of these molecules are useful tools for probing DNA structure and as therapeutically useful radiosensitizing agents....
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| Autors principals: | , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2010
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2813935/ https://ncbi.nlm.nih.gov/pubmed/20067226 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jo902071y |
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