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The Algal Hepatoxoxin Okadaic Acid is a Substrate for Human Cytochromes CYP3A4 and CYP3A5
The hepatotoxin okadaic acid (OA) was incubated with nine human recombinant cytochrome P450s (1A1, 1A2, 2C8, 2C9, 2C19, 2D6, 2E1, 3A4 and 3A5). Both CYP3A4 and CYP3A5 converted OA to a mixture of the same four metabolites, but incubation with CYP3A4 resulted in higher levels of conversion. Michaelis...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2813889/ https://ncbi.nlm.nih.gov/pubmed/19699225 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.toxicon.2009.08.007 |
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