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Discovery of New GPCR biology – One Receptor Structure at a Time

G protein-coupled receptors (GPCRs) are the largest family of proteins in the human genome. They transmit an exogenous signal to the intracellular second messenger cascade by ligand induced conformational changes within a common seven transmembrane helical bundle. Due to their critical role in biolo...

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Autors principals: Hanson, Michael A., Stevens, Raymond C.
Format: Artigo
Idioma:Inglês
Publicat: 2009
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2813843/
https://ncbi.nlm.nih.gov/pubmed/19141277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2008.12.003
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