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Stabilization of the β2-adrenergic Receptor 4-3-5 Helix Interface by Mutagenesis of Glu-122(3.41), A Critical Residue in GPCR Structure
SUMMARY: G protein-coupled receptor (GPCR) instability represents one of the most profound obstacles to the structural study of GPCRs that bind diffusible ligands. The introduction of targeted mutations at non-conserved residues that lie proximal to helix interfaces has the potential to enhance the...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2292833/ https://ncbi.nlm.nih.gov/pubmed/18222471 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2007.12.028 |
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