Stabilization of the β2-adrenergic Receptor 4-3-5 Helix Interface by Mutagenesis of Glu-122(3.41), A Critical Residue in GPCR Structure

SUMMARY: G protein-coupled receptor (GPCR) instability represents one of the most profound obstacles to the structural study of GPCRs that bind diffusible ligands. The introduction of targeted mutations at non-conserved residues that lie proximal to helix interfaces has the potential to enhance the...

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Bibliographic Details
Main Authors: Roth, Christopher B., Hanson, Michael A., Stevens, Raymond C.
Format: Artigo
Language:Inglês
Published: 2007
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2292833/
https://ncbi.nlm.nih.gov/pubmed/18222471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2007.12.028
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