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Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution

To explore the mechanisms and evolution of cell-cycle control, we analyzed the position and conservation of large numbers of phosphorylation sites for the cyclin-dependent kinase Cdk1 in the budding yeast Saccharomyces cerevisiae. We combined specific chemical inhibition of Cdk1 with quantitative ma...

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Detalhes bibliográficos
Main Authors: Holt, Liam J., Tuch, Brian B., Villén, Judit, Johnson, Alexander D., Gygi, Steven P., Morgan, David O.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2813701/
https://ncbi.nlm.nih.gov/pubmed/19779198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1172867
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