SIRT1 Decrease Parallels the Accumulation of tau in Alzheimer Disease

Aging and metabolism-related disorders are risk factors for Alzheimer disease (AD). Since sirtuins may increase the lifespan through regulation of cellular metabolism, we compared the concentration of sirtuin 1 (SIRT1) in the brains of AD patients (n = 19) and controls (n = 22) using Western immunob...

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Bibliographic Details
Main Authors: Julien, Carl, Tremblay, Cyntia, Émond, Vincent, Lebbadi, Meryem, Salem, Norman, Bennett, David A., Calon, Frédéric
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2813570/
https://ncbi.nlm.nih.gov/pubmed/19104446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/NEN.0b013e3181922348
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